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KMID : 0378019710140100109
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New Medical Journal
1971 Volume.14 No. 10 p.109 ~ p.112
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Influence of Panax Ginseng upon rectal temperature of young rats exposed to cold
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Abstract
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A study was planned to evaluate the effect of Panax Ginseng upon the rectal temperature of young rats in cold environment.
Forty young male rats (body weight: 40-50 gm)were divided equally into a ginseng and a saline group. For 15 days the ginseng group received every day 0. 5 ml/100 gm body weight of ginseng extract solution
(4 mg of 95%-alcohol extract dissolved in 1 ml of saline) subcutaneously, while the saline group received I the same amount of saline. From the 5th experimental day on, each animal was immobilized 2 hr after the drug on a wooden board and exposed to cold (0°C) for 30 min every day for 10 consecutive days. On the 1st, 5th, and 10th exposure day, the rectal temperature of each animal was measured before and during cold exposure using a needle-type thermister connected to a micropyrometer.
Results obtained were as follows:
1. The rectal temperature of the young ginseng group was not significantly different from that of the young saline group before exposure to cold.
2. The rectal temperature of the ginseng group was higher than that of the saline group during the
1st exposure to cold, but it became significantly lower than that of the saline group upon repeated
exposure to cold.
The inferences from the above results are that the ginseng has no significant influence upon rectal j temperature of young rats without cold exposure, and that although the ginseng tends to prevent drop in rectal temperature at the 1st exposure to cold, it facilitates the drop in temperature as the exposure is repeated, presumably because the drug accelerates responses of animals to cold stress.
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